The film tells the story of two people with Asperger syndrome (a form of autism). Donald (Josh Hartnett) runs a small self-help group for people on the autism spectrum who are more affected by their autism than he is. Isabelle (Radha Mitchell) is referred to the group by her therapist. Mozart and the Whale is a fictional account, using characters loosely based on the real-life relationship of Jerry Newport and Mary Meinel (now Mary Newport).
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